genetic risk factors for periodontal disease

Richa Sharma MDS 2nd yr Dept of Periodontology and Oral Implantology 2. If you have a family history of gum disease, then you are more likely to have problems with your gums. Destructive periodontal disease is a consequence of the interaction of genetic, environmental, host and micro- bial factors.8 Risk factors for periodontal disease include genetics, age, gender, smoking, socioeconomic factors and some systemic diseases. Data . Start studying PER 712 Risk factors for periodontal diseases: genetics. These risk factors are modifiable and their management is a major component of the contemporary care of many periodontal patients. In fact, recent studies have shown that tobacco use may be one of the most significant risk factors and smokers are three times more likely to develop periodontal disease compared with non-smokers. RISK FACTORS 1.1. cigarette smoking 1.2. diabetes mellitus 1.3. low education attainment 1.4. genetic predispositions 2. This disease usually starts out as gingivitis, which is characterized by … Learn vocabulary, terms, and more with flashcards, games, and other study tools. Based on this most recent review, it seems that genetic factors play a significant, but far-from-overwhelming role in periodontal disease risk. Family studies suggest that susceptibility to the early onset forms of disease, particularly prepubertal and juvenile periodontitis, is, at least in part, influenced by host genotype. Smoking dries the mouth, which is an attractive environment for harmful bacteria. Genetic factors and periodontal disease 1. Several studies indicate that may persons have a predisposal to gum disease. During the event, he revealed that both diseases share a genetic basis involving the VAMP8 function. Genetic and heritable risk factors in periodontal disease. Objectives . For the last 20 years, the periodontal community has followed the classification of two distinct phenotypes of periodontitis: aggressive periodontitis (AgP) and chronic periodontitis (CP). Systemic risk factors and risk indicators for periodontal disease • Systemic risk factors include smoking, diabetes mellitus, race, genetic factors, male gender, polymorphonuclear (PMN) functional abnormalities, low economic status, low educational level, acquired systemic infections such as human immunodeficiency virus (HIV), and severe malnutrition ( Table 11.1 ). • A risk predictor/marker although associated with increased risk for disease, do not cause the disease. 12.Michalowicz BS. PERIODONTAL DISEASE by poofclam - 1. contributions by genes that may modify periodontal disease expression.9 Other important factors, such as environmental (particularly smoking) and micro-bial agents (virulence factors), also modify disease risk and expression.3-5,17 Polymorphism The major genetic factors in complex disease models are not single mutations that dramatical- T he purpose of this paper is to review current knowledge of genetic risk factors for the periodontal diseases and to present updated and additional data from the Minnesota Twin Periodontal Study. Genetics. Genetics: Genetic risk factors influence one’s susceptibility and progression of gum disease. Genetic factors and heritable risk factors in periodontal disease: Highly sophisticated DNA analysis techniques have recently demonstrated that the transmission among family members can and does occur . DEFINITION 2.1. chronic inflammatory conditions of the gingiva, bone and ligament supporting the teeth 3. Almost 70% of patients who have periodontal disease are smokers, current or past. Within the domain of genetic risk factors for periodontitis, not only do certain genetic variations play a role, epigenetic changes in DNA are also involved. Family studies suggest that susceptibility to the early onset forms of disease, particularly prepubertal and juvenile periodontitis, is, at least in part, influenced by host genotype. Table 1 provides a simple classification system for these factors. The aims of this chapter are two-fold: first, to outline the key aspects of history taking in child, adolescent and young adult patients with periodontal problems; and secondly, to identify the principal systemic periodontal risk factors in these age groups that may be identified from the history. Identification of genetic risk factors for periodontitis and possible mechanisms of action. Chapter 3 History and Systemic Risk Factors for Periodontal Diseases Aims . Implants in function for a significant number years can develop peri-implantitis. But first, let’s discuss the risk factors that are not within your control. Risk Factors of Periodontal Disease: Review of the Literature Yousef A. AlJehani Dental Health Department, Colleg e of Applied Medical Sciences, K ing Saud University, P .O. Smoking also can make treatment for gum disease less successful. 1994; 65: 479-488. J Clin Periodontol. 1 The risk factors for periodontal diseases can be broadly classified as individual and local. Periodontal diseases are multi-factorial, meaning that susceptibility to the disease involves genetic as well as environmental factors such as diet, smoking, and other lifestyle factors. Risk factors for periodontal diseases include microbiologic factors, immunologic factors, environmental factors, and genetic factor. In fact, most of the risk factors for gum disease are within your control. J Periodontol. Table 1. Periodontal disease increases with age; 70.1% of adults 65 years and older have periodontal disease” (CDC, 2015). The reason is that some risk factors for gum disease relate more to behavior than genetics or overall health. Many people are born with a “sensitivity” to plaque bacteria – making their periodontal disease much worse due… INTRODUCTION Bacteria cause periodontal disease, but other factors determine how severe that disease will become and how specific a patient responds to the therapy. PATHOPHYSIOLOGY 3.1. dental plaque 3.2. microbial biofilm 3.3. immunopathogenesis 11.Loos BG, John RP, Laine ML. Periodontal disease, like caries, is complex and multifactorial, but shares more of a direct link with overall health, so that risk factors such as smoking and diabetes can significantly contribute to its etiology. One third of the population have a genetic tendency to develop periodontal disease. Your genes play a major role in the onset and severity of periodontal diseases. Genetic risk factor’s for Periodontal Disease Could my periodontal disease be genetic? The most common risk factors for developing gum disease are: Genetic factors. Risk factors of the gum disease ... medicines and medical condition of the person can also trigger gum disease. Other risk factors include diabetes; hormonal changes in girls and women; diabetes; medications that lessen the flow of saliva; certain illnesses, such as AIDS, and their medications; and genetic susceptibility. Genetic factors also play a role in periodontal disease and allow one to target individuals for prevention and early detection. Original articles that reported on the risk factors for periodontal disease were included. The risk factors for developing these diseases are prior history of periodontitis, poor oral hygiene, smoking, diabetes, implant cement beyond the margin of the crown, occlusal overload and genetic factors. K eyWoRDs : Aggressive, chronic, genetic, gingivitis, periodontitis, polymorphism, single nucleotide, syndrome 1,2. Although previous research has demonstrated an association between coronary artery disease and periodontal disease due to risk factors such as diabetes, there weren’t many that compared their genetic … According to the American Dental Association, genetics is a risk factor for developing gum disease. Smoking/Vaping: This is the strongest environmental risk factor for periodontal disease. Instead, environmental effects, including oral hygiene and regular dental visits , still play the primary role in determining overall risk. The role of genetic factors in aggressive periodontitis is clear. These responses are influenced by local, systemic, genetic and environmental risk factors. on genetic risk factors and its influence for the various forms of periodontal disease. Sources . • Risk indicator is used to describe a putative (or potential) risk factor identified to be associated with disease from case control or cross-sectional studies, but not yet confirmed in longitudinal or interventional studies. Periodontal disease was also significantly associated with an increased risk of prostate cancer in men and with cancer of the corpus uteri in women. 2005; 32 Suppl 6: 159-179. Gingivitis is a reversible condition whereas periodontitis is irreversible condition, in which along with inflammation of gingiva, destruction of tooth-supporting structure occurs. Gingivitis is the inflammation of gingiva. Periodontitis is a multifactorial inflammatory disease and both environmental and genetic factors play a major role in the progression of the disease with consequent tissue destruction around the dental roots, and alveolar bone is associated with systemic alterations such as diabetes , changes in the liver , cardiovascular diseases , and even osteoporosis . These factors can increase your risk of periodontal disease or make it worse once the infection has set in. Individuals with periodontal disease had an increased risk of lung cancer; however, after adjustment for smoking and other risk factors, this association was no longer statistically significant. ... Genetic tests are done to determine the susceptibility of a person to the gum disease.

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